Laboratorium Neurobiologii Molekularnej i Komórkowej

Prentzell MT et al. (Jaworski J, Kedra M, Kopach A, Macias M, Zmorzynska J.)

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling.

Koscielny A, Liszewska E, Machnicka K, Wezyk M, Kotulska K, Jaworski J.

mTOR controls endoplasmic reticulum-Golgi apparatus trafficking of VSVg in specific cell types.

Liszewska E, Majchrowicz L, Krogulec E, Kotulska K, Kaczmarek L, Kalita K, Dobrzyń A, Jaworski J.

Establishment of two hiPSC lines (IIMCBi001-A and IIMCBi002-A) from dermal fibroblasts of healthy donors and characterization of their cell cycle.

Ogórek B, Hamieh L, Hulshof HM, Lasseter K, Klonowska K, Kuijf H, Moavero R, Hertzberg C, Weschke B, Riney K, Feucht M, Scholl T, Krsek P, Nabbout R, Jansen AC, Benova B, Aronica E, Lagae L, Curatolo P, Borkowska J, Sadowski K, Domańska-Pakieła D, Janson S, Kozlowski P, Urbanska M, Jaworski J, Jozwiak S, Jansen FE, Kotulska K; EPISTOP Consortium members, Kwiatkowski DJ.

TSC2 pathogenic variants are predictive of severe clinical manifestations in TSC infants: results of the EPISTOP study.

Tempes A, Weslawski J, Brzozowska A, Jaworski J.

Role of dynein-dynactin complex, kinesins, motor adaptors and their phosphorylation in dendritogenesis.

Kedra M, Banasiak K, Kisielewska K, Wolinska-Niziol L, Jaworski J, Zmorzynska J.

TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex.

Samluk L, Urbanska M, Kisielewska K, Mohanraj K, Kim MJ, Machnicka K, Liszewska E, Jaworski J, Chacinska A.

Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress.

McIntyre J, Sobolewska A, Fedorowicz M, McLenigan MP, Macias M, Woodgate R, Sledziewska-Gojska E.

DNA polymerase ι is acetylated in response to SN2 alkylating agents.

Rojek KO, Krzemień J, Doleżyczek H, Boguszewski PM, Kaczmarek L, Konopka W, Rylski M, Jaworski J, Holmgren L, Prószyński TJ.

Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice.

Tarkowski B, Kuchcinska K, Blazejczyk M, Jaworski J.

Pathological mTOR mutations impact cortical development.

Urbanska M⁠⁠,⁠ Kazmierska-Grebowska⁠ P, Kowalczyk⁠ T., Caban B⁠, Nader⁠ K, Pijet⁠ B, Kalita ⁠K, Gozdz⁠ A, Devijver⁠e H, Lechat⁠e B, Jaworski T⁠, Grajkowska⁠ W, Sadowski⁠ K, Jozwiak⁠ S⁠,⁠ Kotulska⁠ K, Konopacki⁠ J, Van Leuven⁠ F, van Vliet⁠h E⁠, Aronica⁠ E⁠,⁠ Jaworski⁠ J.

GSK3β activity alleviates epileptogenesis and limits GluA1 phosphorylation.

Firkowska M, Macias M, Jaworski J.

ESCRT Proteins Control the Dendritic Morphology of Developing and Mature Hippocampal Neurons.

Urbanska M, Gozdz A, Macias M, Cymerman IA, Liszewska E, Kondratiuk I, Devijver H, Lechat B, Van Leuven F, Jaworski J.

GSK3β Controls mTOR and Prosurvival Signaling in Neurons.

Koscielny A, Malik AR, Liszewska E, Zmorzynska J, Tempes A, Tarkowski B, Jaworski J

Adaptor Complex 2 Controls Dendrite Morphology via mTOR-Dependent Expression of GluA2

de Hoz L, Gierej D, Lioudyno V, Jaworski J, Blazejczyk M, Cruces-Solís H, Beroun A, Lebitko T, Nikolaev T, Knapska E, Nelken I, Kaczmarek L

Blocking c-Fos Expression Reveals the Role of Auditory Cortex Plasticity in Sound Frequency Discrimination Learning

Jaworski J, Kalita K, Knapska E.

c-Fos and neuronal plasticity: the aftermath of Kaczmarek's theory.

Liszewska E, Jaworski J.

Neural Stem Cell Dysfunction in Human Brain Disorders.

Kuzniewska B, Sadowski K, Urbanska K, Urbanska M, Kotulska K, Liszewska E, Grajkowska W, Jóźwiak S, Dziembowska M.

The level of microRNA 21 is upregulated by rapamycin in serum of tuberous sclerosis complex patients and subependymal giant cell astrocytoma (SEGA)-derived cell cultures.

Hareza A, Bakun M, Świderska B, Dudkiewicz M, Koscielny A, Bajur A, Jaworski J, Dadlez M, Pawłowski K.

Phosphoproteomic insights into processes influenced by the kinase-like protein DIA1/C3orf58.

Kondratiuk I, Łęski S, Urbańska M, Biecek P, Devijver H, Lechat B, Van Leuven F, Kaczmarek L, Jaworski T

GSK-3β and MMP-9 Cooperate in the Control of Dendritic Spine Morphology

Gozdz A, Nikolaienko O, Urbanska M, Cymerman IA, Sitkiewicz E, Blazejczyk M, Dadlez M, Bramham CR, Jaworski J

GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation

Urbanska AS, Janusz-Kaminska A, Switon K, Hawthorne AL, Perycz M, Urbanska M, Bassell GJ, Jaworski J

ZBP1 phosphorylation at serine 181 regulates its dendritic transport and the development of dendritic trees of hippocampal neurons

Kononenko NL, Claßen GA, Kuijpers M, Puchkov D, Maritzen T, Tempes A, Malik AR, Skalecka A, Bera S, Jaworski J, Haucke V

Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration

Switon K, Kotulska K, Janusz-Kaminska A, Zmorzynska J, Jaworski J

Molecular neurobiology of mTOR

Blazejczyk M, Macias M, Korostynski M, Firkowska M, Piechota M, Skalecka A, Tempes A, Koscielny A, Urbanska M, Przewlocki R, Jaworski J

Kainic Acid Induces mTORC1-Dependent Expression of Elmo1 in Hippocampal Neurons

Switon K, Kotulska K, Janusz-Kaminska A, Zmorzynska J, Jaworski J

Tuberous sclerosis complex: From molecular biology to novel therapeutic approaches

Wasiak I, Kulikowska A, Janczewska M, Michalak M, Cymerman IA, Nagalski A, Kallinger P, Szymanski WW, Ciach T

Dextran Nanoparticle Synthesis and Properties

Lipka J, Kapitein LC, Jaworski J, Hoogenraad CC

Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites

Kevenaar JT, Bianchi S, van Spronsen M, Olieric N, Lipka J,Frias CP, Mikhaylova M, Harterink M, Keijzer N, Wulf PS, Hilbert M, Kapitein LC, de Graaff E, Ahkmanova A, Steinmetz MO, Hoogenraad CC

Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity

van Scheppingen J, Iyer AM, Prabowo AS, Mühlebner A, Anink JJ, Scholl T, Feucht M, Jansen FE, Spliet WG, Krsek P, Zamecnik J, Buccoliero AM, Giordano F, Genitori L, Kotulska K, Jozwiak S, Jaworski J, Liszewska E, van Vliet EA, Aronica E

Expression of microRNAs miR21, miR146a, and miR155 in tuberous sclerosis complex cortical tubers and their regulation in human astrocytes and SEGA-derived cell cultures

Skałecka A, Liszewska E, Bilinski R, Gkogkas C, Khoutorsky A, Malik AR, Sonenberg N, Jaworski J

mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons

Jasińska M, Miłek J, Cymerman IA, Łęski S, Kaczmarek L, Dziembowska M

miR-132 Regulates Dendritic Spine Structure by Direct Targeting of Matrix Metalloproteinase 9 mRNA

Kędra M, Jaworski J, Zmorzyńska J.

Okiem ryby - nowe spojrzenie na rozwój sieci neuronalnych i choroby neurorozwojowe.

Kulcenty K, Wróblewska J, Mazurek S, Liszewska E, Jaworski J.

Molecular mechanisms of induced pluripotency.

Esteves da Silva M, Adrian M, Schätzle P, Lipka J, Watanabe T, Cho S, Futai K, Wierenga CJ, Kapitein LC, Hoogenraad CC

Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture

Malik AR, Liszewska E, Skalecka A, Urbanska M, Iyer AM, Swiech LJ, Perycz M, Parobczak K, Pietruszka P, Zarebska MM, Macias M, Kotulska K, Borkowska J, Grajkowska W, Tyburczy ME, Jozwiak S, Kwiatkowski DJ, Aronica E, Jaworski J

Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase

Malik AR, Liszewska E, Jaworski J

Matricellular proteins of the Cyr61/CTGF/NOV (CCN) family and the nervous system

Cymerman IA, Gozdz A, Urbanska M, Milek J, Dziembowska M, Jaworski J

Structural Plasticity of Dendritic Spines Requires GSK3α and GSK3βMistargeted mitochondrial proteins activate a proteostatic response in the cytosol

Geiger JC, Lipka J, Segura I, Hoyer S, Schlager MA, Wulf PS, Weinges S, Demmers J, Hoogenraad CC, Acker-Palmer A

The GRIP1/14-3-3 Pathway Coordinates Cargo Trafficking and Dendrite Development

Skupien A, Konopka A, Trzaskoma P, Labus J, Gorlewicz A, Swiech L, Babraj M, Dolezyczek H, Figiel I, Ponimaskin E, Wlodarczyk J, Jaworski J, Wilczynski GM, Dzwonek J

CD44 regulates dendrite morphogenesis through Src tyrosine kinase-dependent positioning of the Golgi

Jaworski J

Uchwytny kształt pamięci

Malik AR, Urbanska M, Macias M, Skalecka A, Jaworski J

Beyond control of protein translation: What we have learned about the non-canonical regulation and function of mammalian target of rapamycin (mTOR)

Malik AR, Urbanska M, Gozdz A, Swiech LJ, Nagalski A, Perycz M, Blazejczyk M, Jaworski J

CYR61, a matricellular protein, is needed for dendritic arborization of hippocampal neurons

van Spronsen M, Mikhaylova M, Lipka J, Schlager MA, van den Heuvel DJ, Kuijpers M, Wulf PS, Keijzer N, Demmers J, Kapitein LC, Jaarsma D, Gerritsen HC, Akhmanova A, Hoogenraad CC

TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites

Kuzniewska B, Rejmak E, Malik AR, Jaworski J, Kaczmarek L, Kalita K

Brain-derived neurotrophic factor induces matrix metalloproteinase-9 expression in neurons via serum response factor/c-Fos pathway

Kapitein LC, van Bergeijk P, Lipka J, Keijzer N, Wulf PS, Katrukha EA, Akhmanova A, Hoogenraad CC

Myosin-V Opposes Microtubule-Based Cargo Transport and Drives Directional Motility on Cortical Actin

Macias M, Blazejczyk M, Kazmierska P, Caban B, Skalecka A, Tarkowski B, Rodo A, Konopacki J, Jaworski J

Spatiotemporal Characterization of mTOR Kinase Activity Following Kainic Acid Induced Status Epilepticus and Analysis of Rat Brain Response to Chronic Rapamycin Treatment

Bedzhov I, Alotaibi H, Basilicata MF, Ahlborn K,Liszewska E, Brabletz T, Stemmler MP

Adhesion, but not a specific cadherin code, is indispensable for ES cell and induced pluripotency

Janusz A, Milek J, Perycz M, Pacini L, Bagni C, Kaczmarek L, Dziembowska M

The fragile x mental retardation protein regulates matrix metalloproteinase 9 mRNA at synapses

Lipka J, Kuijpers M,Jaworski J, Hoogenraad CC

Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases

Liszewska E, Jaworski J

Why do we need induced pluripotent stem cells in neurobiology?

Knapska E, Macias M, Mikosz M, Nowak A, Owczarek D, Wawrzyniak M, Pieprzyk M, Cymerman IA, Werka T, Sheng M, Maren S, Jaworski J, Kaczmarek L

Functional anatomy of neural circuits regulating fear and extinction

Urbanska M, Gozdz A, Swiech LJ, Jaworski J

Mammalian target of rapamycin complex 1 (MTORC1) and 2 MTORC2) control the dendritic arbor morphology of hippocampal neurons

Urbanska M, Swiech L, Jaworski J

Developmental plasticity of the dendritic compartment: focus on the cytoskeleton

Azoulay-Alfaguter I, Yaffe Y, Licht-Murava A, Urbanska M, Jaworski J, Pietrokovski S, Hirschberg K, Eldar-Finkelman H

Distinct molecular regulation of glycogen synthase kinase-3alpha isozyme controlled by its N-terminal region: functional role in calcium/calpain signaling

Swiech L, Blazejczyk M, Urbanska M, Pietruszka P, Dortland BR, Malik AR, Wulf PS, Hoogenraad CC, Jaworski J

CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology

Kapitein LC, Yau KW, Gouveia SM, van der Zwan WA, Wulf PS, Keijzer N, Demmers J, Jaworski J, Akhmanova A, Hoogenraad CC

NMDA Receptor Activation Suppresses Microtubule Growth and Spine Entry

Perycz M, Urbanska AS, Krawczyk PS, Parobczak K, Jaworski J

Zipcode binding protein 1 regulates the development of dendritic arbors in hippocampal neurons

Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM

2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family

Kieper J, Lauber C, Gimadutdinow O, Urbańska A, Cymerman I, Ghosh M, Szczesny B, Meiss G

Production and characterization of recombinant protein preparations of Endonuclease G-homologs from yeast, C. elegans and humans.

Stefaniuk M, Swiech L, Dzwonek J, Lukasiuk K

Expression of Ttyh1, a member of the Tweety family in neurons in vitro and in vivo and its potential role in brain pathology.

Piechota M, Korostynski M, Solecki W, Gieryk A, Slezak M, Bilecki W, Ziolkowska B, Kostrzewa E, Cymerman I, Swiech L, Jaworski J, Przewlocki R

The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum.

Blazejczyk M, Sobczak A, Debowska K, Wisniewska MB, Kirilenko A, Pikula S, Jaworski J, Kuznicki J, Wojda U.

Biochemical characterization and expression analysis of a novel EF-hand Ca2+ binding protein calmyrin2 (Cib2) in brain indicates its function in NMDA receptor mediated Ca2+ signaling.

Jaworski J, Kapitein LC, Gouveia SM, Dortland BR, Wulf PS, Grigoriev I, Camera P, Spangler SA, Di Stefano P, Demmers J, Krugers H, Defilippi P, Akhmanova A, Hoogenraad CC

Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity.

Mioduszewska B, Jaworski J, Szklarczyk AW, Klejman A, Kaczmarek L

Inducible cAMP early repressor (ICER)-evoked delayed neuronal death in the organotypic hippocampal culture

Tomat E, Nolan EM, Jaworski J, Lippard SJ

Organelle-specific zinc detection using zinpyr-labeled fusion proteins in live cells

Urbanska M, Blazejczyk M, Jaworski J

Molecular basis of dendritic arborization

Macias M

Injury induced dendritic plasticity in the mature central nervous system.

Swiech L, Perycz M, Malik A, Jaworski J

Role of mTOR in physiology and pathology of the nervous system

Jaworski J, Hoogenraad CC, Akhmanova A

Microtubule plus-end tracking proteins in differentiated mammalian cells.

Rylski M, Amborska R, Zybura K, Mioduszewska B, Michaluk P, Jaworski J, Kaczmarek L

Yin Yang 1 is a critical repressor of matrix metalloproteinase-9 expression in brain neurons

Jaworski J

ARF6 in the nervous system.

Michaluk P, Kolodziej L, Mioduszewska B, Wilczynski GM, Dzwonek J, Jaworski J, Gorecki DC, Ottersen OP, Kaczmarek L

Beta-dystroglycan as a target for MMP-9, in response to enhanced neuronal activity.

Okulski P, Jay TM, Jaworski J, Duniec K, Dzwonek J, Konopacki FA, Wilczynski GM, Sánchez-Capelo A, Mallet J, Kaczmarek L

TIMP-1 abolishes MMP-9-dependent long-lasting long-term potentiation in the prefrontal cortex.

Jaworski J, Sheng M

The growing role of mTOR in neuronal development and plasticity

Nolan EM, Ryu JW, Jaworski J, Feazell RP, Sheng M, Lippard SJ

Zinspy sensors with enhanced dynamic range for imaging neuronal cell zinc uptake and mobilization.

Szymczak S, Kalita K, Jaworski J, Mioduszewska B, Savonenko A, Markowska A, Merchenthaler I, Kaczmarek L

Increased estrogen receptor beta expression correlates with decreased spine formation in the rat hippocampus