Role of ESCRT-I protein complex in amino acid and lipid metabolism in the context of erythropoiesis

Project number:

POIR.04.04.00-00-1C54/16

Title:

Role of ESCRT-I protein complex in amino acid and lipid metabolism in the context of erythropoiesis

Project leader:

Jarosław Cendrowski, PhD
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Team members:

Michał Mazur (Master student)

Duration:

 01.01.2017 – 31.12.2018

About the project:             

The endosomal sorting complexes required for transport (ESCRTs) constitute a cellular system for membrane remodeling. I discovered that ESCRT-I depleted cells show reduced expression of genes encoding  enzymes of amino acid and fatty acid metabolism. I also found that mRNA levels of ESCRT-I subunits are up-regulated during erythropoiesis. Both membrane turnover and metabolic regulation are essential for erythropoiesis, however ESCRT-I function or the interrelation between membrane and metabolic homeostasis in erythroid maturation have not been described. The aim of my project is to study the role of ESCRT-I in cellular metabolism in the context of erythropoiesis.