Cellular consequences of endosomal dysfunction for proteostasis, metabolism and cancer biology

Project number:

POIR.04.04.00-00-20CE/16

Title:

Cellular consequences of endosomal dysfunction for proteostasis, metabolism and cancer biology

Project leader:

Marta Miączyńska, PhD, Professor
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Team members:

Krzysztof Kolmus (post-doc)
Kamil Jastrzębski (post-doc)
Marta Kaczmarek (PhD Student)
Karolina Wojciechowska (PhD Student)
Purevsuren Erdenebat (master student)
Małgorzata Świątek (master student)

Duration:

01.06.2017–28.02.2021

About the project:             

The project combines molecular cell biology and cancer biology. It aims to elucidate the consequences of endosomal dysfunction in mammalian cells and their contribution to tumorigenesis. The experimental work involves biochemical, microscopy and transcriptomic techniques to investigate metabolic processes, membrane transport and signal transduction in cultured cells. Moreover, in collaboration with scientists from the Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology in Warsaw, we are also investigating the function of endosomes in cancer cells and the possibility of its pharmacological modulation.