The regulation of methionine metabolism by the ubiquitin-proteasome system: CHIPed supervision of the methylation potential

Project number:

POIR.04.04.00-00-5EAB/18-00

Title:

The regulation of methionine metabolism by the ubiquitin-proteasome system: CHIPed supervision of the methylation potential

Project leader:

Wojciech Pokrzywa, PhD
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Team members:

Katarzyna Banasiak (PhD student), Michał Chojnacki (post-doc)

Duration:

01.12.2018–28.02.2022

About the project:             

Regulation of methionine metabolism by the ubiquitin-proteasome system
S-adenosyl-L-methionine (SAM) dependent methylation is central to the regulation of many biological processes including gene expression, signaling, protein synthesis, and lipid metabolism. SAM is synthesized in the cytosol of every cell from L-methionine and ATP, in a reaction catalyzed by methionine adenosyltransferase. Despite fundamental roles of the SAM cycle in a broad range of biological processes, the mechanisms of its regulation are still enigmatic. Our preliminary studies suggest that the ubiquitin-proteasome system (UPS) controls SAM cycle activity. We aim to understand how the UPS modulates the methionine metabolism, methylation potential of the cell and epigenetic memory using C. elegans as an animal model. In addition, the proposed research will have broad implications for the understanding of methionine metabolism regulation in health and disease and protein homeostasis mechanisms in general.