Postdoctoral researcher

Laboratory of Iron Homeostasis at the International Institute of Molecular and Cell Biology (IIMCB), Warsaw, headed by Dr Katarzyna Mleczko - Sanecka, is looking for Postdoctoral Fellow.

You will join the project entitled “Deciphering novel mechanisms that control iron sensing and iron accumulation in the liver”, which is carried out as theOPUS 2018/31/B/NZ4/03676 grant of the Polish National Science Centre. The project provides a unique opportunity to develop cutting-edge cell-based and in vivo (mouse) methodologies to better understand still elusive mechanisms that may modify iron and manganese homeostasis. Specifically, we aim to elucidate how the expression of ZIP14, a transporter responsible for uptake of these metal ions into hepatocytes, is controlled. This challenging project will involve external collaborators and is expected to have clinical implications for the management of patients with iron overload disorders.

As a Postdoctoral Researcher: you will take over an already initiated and very promising project to further decipher the ZIP14 regulatory mechanism. You will combine in vitro work (including CRISPR-mediated gene knock-outs and cultures of primary hepatocytes) and mouse-based studies (dietary manipulations, drug treatments and prospectively AAV-mediated CRISPR knock-outs in vivo).

The ideal candidate should be able to pursue challenging tasks, think independently, achieve objectives and collaborate with other researchers. Candidates will be selected in an open competition, according to the procedure complying with the rules of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers as a part of HR Excellence in Research strategy https://www.iimcb.gov.pl/en/institute/hr-excellence

The laboratory is located in the International Institute of Molecular and Cell Biology in Warsaw (www.iimcb.gov.pl) – one of the top-ranked (A+) Polish research institutes, that provides stimulating and interdisciplinary research environment and opportunities of the large biomedical campus. Research topics at IIMCB cover the wide area of structural biology, bioinformatics, computer modeling, molecular and cell biology, neurobiology, cancer biology, and developmental genomics (zebrafish model). The Institute is equipped with state-of-the-art technology, has excellent core facilities and supportive administration. IIMCB benefits from numerous generous funding schemes for basic research through grants from international and national sourceswww.iimcb.gov.pl/en/research/grants).

Requirements for the candidate:

1. Holds a doctoral degree/Ph.D. in biology, biotechnology, medicine or related field at the moment of starting the job.

2. Fulfills the formal criteria of the competition in particular section 2.1.1 https://www.ncn.gov.pl/sites/default/files/pliki/uchwaly-rady/2018/uchwala76_2018-zal1.pdf

3. Has excellent knowledge of molecular and cell biology.

4. Has expertise or shows strong interests in iron biology, has motivation for experimental work, passion for science.

5. Gathered extensive experience in laboratory work, including basic molecular biology techniques, cell culture and mouse-based studies.

6. Prior experience with large-scale experiments and bioinformatics will be of advantage but not mandatory.

7. Has research achievements well documented by publication record and conference presentations.

8. Shows readiness to learn new skills and take challenges, can work independently and think analytically.

9. Has excellent communication and writing skills.

10. Mobility and research experience abroad will be of advantage but not mandatory.

11. Success in applying for funding would be a plus.

We offer:

• Full employment contract for 2 years (prolongations may be possible)

• Monthly full remuneration cost approximately 10000 PLN (approx. 6000 PLN net)*

• The position with 100% focus on research (no teaching obligations)

• Benefits including reduced-rate for an individual medical care package and membership in MultiSport programme

• Full technical, administrative and organizational support from professional English-speaking personnel

• Participation in courses, scientific training, support from peers, and academic mentoring

The deadline for applications is October 26th, 2020 (but can be prolonged if no suitable candidates are found). Job starting date is December2020 (it will also depend on the current epidemiological situation).

How to apply:

• Apply now to Ten adres pocztowy jest chroniony przed spamowaniem. Aby go zobaczyć, konieczne jest włączenie w przeglądarce obsługi JavaScript.

• In the subject include "PostdocOPUS_LIH" and your first and last name.

• Your application must be submitted in English and should contain a CV, a motivation letter, a description of your key achievements, and contact details at least two potential referees, including one of your supervisors

• Please include the following statement in your application: “I hereby agree to the processing of my personal data, included in the application documents by the International Institute of Molecular and Cell Biology in Warsaw, 4 KsięciaTrojdena Street, 02-109 Warsaw, for thepurpose of carryingout thecurrent recruitment process.” Your personal data will be processed for the purpose of the recruitment procedure by the International Institute of Molecular and cell Biology in Warsaw.Full information is available under the link https://www.iimcb.gov.pl/pl/information-clause
  
  
  The competition may be extended until a suitable candidate who fulfils all requirements is found.

* Additional bonuses such as the 13th salary (after working for the institute for six months in a given calendar year) or Christmas bonus may supplement this salary.