HSPA2 Chaperone Contributes to the Maintenance of Epithelial Phenotype of Human Bronchial Epithelial Cells but Has Non-Essential Role in Supporting Malignant Features of Non-Small Cell Lung Carcinoma, MCF7, and HeLa Cancer Cells.

Cancers (Basel)

Chen L, Olszewski MB, Kruithof-de MJ, Snaar-Jagalska BE.

Zebrafish Microenvironment Elevates EMT and CSC-Like Phenotype of Engrafted Prostate Cancer Cells.

Cells

2019

Klimczak M, Biecek P, Zylicz A, Zylicz M.

Heat shock proteins create a signature to predict the clinical outcome in breast cancer.

Sci Rep.

Kampingaa HH et al. …. (Zylicz A, Zylicz M)

Function, evolution, and structure of J-domain proteins.

Cell Stress Chaperones.

Olszewski MB, Pruszko M, Snaar-Jagalska E, Zylicz A, Zylicz M.

Diverse and cancer type‑specific roles of the p53 R248Q gain‑of‑function mutation in cancer migration and invasiveness.

Int. J. Oncol.

2018

Walerych D, Pruszko M, Zyla L, Wezyk M, Gaweda-Walerych K, Zylicz A.

Wild-type p53 oligomerizes more efficiently than p53 hot-spot mutants and overcomes mutant p53 gain-of-function via a "dominant-positive" mechanism.

Oncotarget

Donzelli S, Milano E, Pruszko M, Sacconi A, Masciarelli S, Iosue I, Melucci E, Gallo E, Terrenato I, Mottolese M, Zylicz M, Zylicz A, Fazi F, Blandino G, Fontemaggi G.

Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages.

Breast Cancer Res.

Wawrzynow B, Zylicz A, Zylicz M.

Chaperoning the guardian of the genome. The two-faced role of molecular chaperones in p53 tumor suppressor action.

BBA-Rev Cancer

Gogler-Pigłowska A, Klarzyńska K, Sojka DR, Habryka A, Głowala-Kosińska M, Herok M, Kryj M, Halczok M, Krawczyk Z, Scieglinska D.

Novel role for the testis-enriched HSPA2 protein in regulating epidermal keratinocyte differentiation.

J Cell Physiol.

2017

Klimczak M, Czerwińska P, Mazurek S, Sozańska B, Biecek P, Mackiewicz A, Wiznerowicz M

TRIM28 epigenetic corepressor is indispensable for stable induced pluripotent stem cell formation

Stem Cell Research

Tracz-Gaszewska Z, Klimczak M, Biecek P, Herok M, Kosinski M, Olszewski MB, Czerwińska P, Wiech M, Wiznerowicz M, Zylicz A, Zylicz M, Wawrzynow B

Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation

Oncotarget

Pruszko M, Milano E, Forcato M, Donzelli S, Ganci F, Di Agostino S, De Panfilis S, Fazi F, Bates DO, Bicciato S, Zylicz M, Zylicz A, Blandino G, Fontemaggi G

The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1

EMBO Rep

2016

Olszewski M, Pruszko M.

Danio pręgowany jako organizm modelowy.

Wszechświat

Pruszko M, Żylicz A.

Białka z rodziny ID w inicjacji i progresji nowotworów (Białka z rodziny ID w inicjacji i progresji nowotworów).

Postępy Biochemii

2015

Jorstad A, Nigro B, Cali C, Wawrzyniak M, Fua P, Knott G.

NeuroMorph: A Toolset for the Morphometric Analysis and Visualization of 3D Models Derived from Electron Microscopy Image Stacks.

Neuroinformatics

2013

Żylicz M.

Biologia syntetyczna: jak powstawało życie na Ziemi?

Nauka

2012

Wiech M, Olszewski MB, Tracz-Gaszewska Z, Wawrzynow B, Zylicz M, Zylicz A

Molecular Mechanism of Mutant p53 Stabilization: The Role of HSP70 and MDM2

PLoS One

2011

Hageman J, van Waarde MA, Zylicz A, Walerych D, Kampinga HH

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

Biochem J

2010

Zubrienė A, Gutkowska M, Matulienė J, Chaleckis R, Michailovienė V, Voroncova A, Venclovas C, Zylicz A, Zylicz M, Matulis D

Thermodynamics of radicicol binding to human Hsp90 alpha and beta isoforms

Biophys Chem

Kvardova V, Hrstka R, Walerych D, Muller P, Matoulkova E, Hruskova V, Stelclova D, Sova P, Vojtesek B

The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin

Mol Cancer

Kirkegaard T, Roth AG, Petersen NH, Mahalka AK, Olsen OD, Moilanen I, Zylicz A, Knudsen J, Sandhoff K, Arenz C, Kinnunen PK, Nylandsted J, Jäättelä M

Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.

Nature

Zurawska A, Urbanski J, Matuliene J, Baraniak J, Klejman MP, Filipek S, Matulis D, Bieganowski P

Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo.

Biochim Biophys Acta

Walerych D, Gutkowska M, Klejman MP, Wawrzynow B, Tracz Z, Wiech M, Zylicz M, Zylicz A

ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein.

J Biol Chem

2009

Szymańska Z, Urbański J, Marciniak-Czochra A

Mathematical modelling of the influence of heat shock proteins on cancer invasion of tissue.

J Math Biol

Walerych D, Olszewski MB, Gutkowska M, Helwak A, Zylicz M, Zylicz A

Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions.

Oncogene

Narayan V, Eckert M, Zylicz A, Zylicz M, Ball KL

Cooperative regulation of the interferon regulatory factor-1 tumor suppressor protein by core components of the molecular chaperone machinery

J Biol Chem

Wawrzynow B, Pettersson S, Zylicz A, Bramham J, Worrall E, Hupp TR, Ball KL

A function for the RING finger domain in the allosteric control of MDM2 conformation and activity.

J Biol Chem

Szymańska Z, Zylicz M

Mathematical modeling of heat shock protein synthesis in response to temperature change.

J Theor Biol

2008

Guranowski A, Wojdyła AM, Pietrowska-Borek M, Bieganowski P, Khurs EN, Cliff MJ, Blackburn GM, Błaziak D, Stec WJ

Fhit proteins can also recognize substrates other than dinucleoside polyphosphates.

FEBS Lett

Sbroggiò M, Ferretti R, Percivalle E, Gutkowska M, Zylicz A, Michowski W, Kuznicki J, Accornero F, Pacchioni B, Lanfranchi G, Hamm J, Turco E, Silengo L, Tarone G, Brancaccio M.

The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1.

FEBS Lett

Stevens C, Pettersson S, Wawrzynow B, Wallace M, Ball K, Zylicz A, Hupp TR

ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1.

FEBS J

Zurawska A, Urbanski J, Bieganowski P

Hsp90n - An accidental product of a fortuitous chromosomal translocation rather than a regular Hsp90 family member of human proteome

Biochim Biophys Acta

2007

Spiechowicz M, Zylicz A, Bieganowski P, Kuznicki J,Filipek A

Hsp70 is a new target of Sgt1-an interaction modulated by S100A6

Biochem Biophys Res Commun

Schneider G, Nieznanski K, Kilanczyk E, Bieganowski P, Kuznicki J, Filipek A

CacyBP/SIP interacts with tubulin in neuroblastoma NB2a cells and induces formation of globular tubulin assemblies.

Biochim Biophys Acta

Wawrzynow B, Zylicz A, Wallace M, Hupp T, Zylicz M

MDM2 chaperones the p53 tumor suppressor.

J Biol Chem

Spiechowicz M, Zylicz A, Bieganowski P, Kuznicki J, Filipek A

Hsp70 is a new target of Sgt1--an interaction modulated by S100A6

Biochem Biophys Res Commun

Issat T, Nowis D, Legat M, Makowski M, Klejman MP, Urbanski J, Skierski J, Koronkiewicz M, Stoklosa T, Brzezinska A, Bil J, Gietka J, Jakóbisiak M, Golab J

Potentiated antitumor effects of the combination treatment with statins and pamidronate in vitro and in vivo.

Int J Oncol

Schneider G, Nieznanski K, Kilanczyk E, Bieganowski P, Kuznicki J, Filipek A

CacyBP/SIP interacts with tubulin in neuroblastoma NB2a cells and induces formation of globular tubulin assemblies.

Biochim Biophys Acta

Wawrzynow B, Zylicz A, Wallace M, Hupp T, Zylicz M

MDM2 chaperones the p53 tumor suppressor.

J Biol Chem

Spiechowicz M, Zylicz A, Bieganowski P, Kuznicki J, Filipek A

Hsp70 is a new target of Sgt1--an interaction modulated by S100A6.

Biochem Biophys Res Commun

Issat T, Nowis D, Legat M, Makowski M, Klejman MP, Urbanski J, Skierski J, Koronkiewicz M, Stoklosa T, Brzezinska A, Bil J, Gietka J, Jakóbisiak M, Golab J

Potentiated antitumor effects of the combination treatment with statins and pamidronate in vitro and in vivo.

Int J Oncol

2006

Kudla G, Lipinski L, Caffin F, Helwak A, Zylicz M

High guanine and cytosine content increases mRNA levels in mammalian cells

PLoS Biol

Galazka G, Stasiolek M, Walczak A, Jurewicz A, Zylicz A, Brosnan CF, Raine CS, Selmaj KW

Brain-derived heat shock protein 70-peptide complexes induce NK cell-dependent tolerance to experimental autoimmune encephalomyelitis.

J Immunol

Bieganowski P, Seidle HF, Wojcik M, Brenner C

Synthetic lethal and biochemical analyses of NAD and NADH kinases in Saccharomyces cerevisiae establish separation of cellular functions.

J Biol Chem

Wojcik M, Seidle HF, Bieganowski P, Brenner C

Glutamine-dependent NAD+ synthetase. How a two-domain, three-substrate enzyme avoids waste.

J Biol Chem

Kudla G, Lipinski L, Caffin F, Helwak A, Zylicz M

High guanine and cytosine content increases mRNA levels in mammalian cells

PLoS Biol

Galazka G, Stasiolek M, Walczak A, Jurewicz A, Zylicz A, Brosnan CF, Raine CS, Selmaj KW

Brain-derived heat shock protein 70-peptide complexes induce NK cell-dependent tolerance to experimental autoimmune encephalomyelitis.

J Immunol

2005

Klejman MP, Zhao X, van Schaik FM, Herr W, Timmers HT

Mutational analysis of BTAF1-TBP interaction: BTAF1 can rescue DNA-binding defective TBP mutants.

Nucleic Acids Res

Ilyushik E, Pryce DW, Walerych D, Riddell T, Wakeman JA, McInerny CJ, McFarlane RJ

Psc3 cohesin of Schizosaccharomyces pombe: cell cycle analysis and identification of three distinct isoforms.

Biol Chem

Bucko-Justyna M, Lipinski L, Burgering BM, Trzeciak L

Characterization of testis-specific serine-threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling.

FEBS J

2004

Mycko MP, Cwiklinska H, Szymanski J, Szymanska B, Kudla G, Kilianek L, Odyniec A, Brosnan CF, Selmaj KW

Inducible heat shock protein 70 promotes myelin autoantigen presentation by the HLA class II.

J Immunol

Walerych D, Kudla G, Gutkowska M, Wawrzynow B, Muller L, King FW, Helwak A, Boros J, Zylicz A, Zylicz M

Hsp90 chaperones wild-type p53 tumor suppressor protein.

J Biol Chem

Jassem J, Jassem E, Jakóbkiewicz-Banecka J, Rzyman W, Badzio A, Dziadziuszko R, Kobierska-Gulida G, Szymanowska A, Skrzypski M, Zylicz M

P53 and K-ras mutations are frequent events in microscopically negative surgical margins from patients with nonsmall cell lung carcinoma.

Cancer

Dworakowska D, Jassem E, Jassem J, Peters B, Dziadziuszko R, Zylicz M, Jakóbkiewicz-Banecka J, Kobierska-Gulida G, Szymanowska A, Skokowski J, Roessner A, Schneider-Stock R

MDM2 gene amplification: a new independent factor of adverse prognosis in non-small cell lung cancer (NSCLC).

Lung Cancer

Mycko MP, Cwiklinska H, Szymanski J, Szymanska B, Kudla G, Kilianek L, Odyniec A, Brosnan CF, Selmaj KW

Inducible heat shock protein 70 promotes myelin autoantigen presentation by the HLA class II.

J Immunol

Kudla G, Helwak A, Lipinski L

Gene conversion and GC-content evolution in mammalian Hsp70.

Mol Biol Evol

Walerych D, Kudla G, Gutkowska M, Wawrzynow B, Muller L, King FW, Helwak A, Boros J, Zylicz A, Zylicz M

Hsp90 chaperones wild-type p53 tumor suppressor protein.

J Biol Chem

Müller L, Schaupp A, Walerych D, Wegele H, Buchner J

Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures.

J Biol Chem

Jassem J, Jassem E, Jakóbkiewicz-Banecka J, Rzyman W, Badzio A, Dziadziuszko R, Kobierska-Gulida G, Szymanowska A, Skrzypski M, Zylicz M

P53 and K-ras mutations are frequent events in microscopically negative surgical margins from patients with nonsmall cell lung carcinoma.

Cancer

Dworakowska D, Jassem E, Jassem J, Peters B, Dziadziuszko R, Zylicz M, Jakóbkiewicz-Banecka J, Kobierska-Gulida G, Szymanowska A, Skokowski J, Roessner A, Schneider-Stock R

MDM2 gene amplification: a new independent factor of adverse prognosis in non-small cell lung cancer (NSCLC).

Lung Cancer

2001

Kaczanowski R, Trzeciak L, Kucharczyk K

Multitemperature single-strand conformation polymorphism.

Electrophoresis

Zylicz M, Wawrzynow A

Insights into the function of Hsp70 chaperones.

IUBMB Life

Zylicz M, King FW, Wawrzynow A

Hsp70 interactions with the p53 tumour suppressor protein

EMBO J

King FW, Wawrzynow A, Höhfeld J, Zylicz M

Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.

EMBO J

Jassem E, Nikliński J, Rosell R, Niklińska W, Jakóbkiewicz J, Monzo M, Chyczewski L, Kobierska G, Skokowski J, Zylicz M, Jassem J

Types and localisation of p53 gene mutations: a report on 332 non-small cell lung cancer patients.

Lung Cancer

Genevaux P, Wawrzynow A, Zylicz M, Georgopoulos C, Kelley WL

DjlA is a third DnaK co-chaperone of Escherichia coli, and DjlA-mediated induction of colanic acid capsule requires DjlA-DnaK interaction.

J Biol Chem

Banecki B, Wawrzynow A, Puzewicz J, Georgopoulos C, Zylicz M

Structure-function analysis of the zinc-binding region of the Clpx molecular chaperone.

J Biol Chem

Kaczanowski R, Trzeciak L, Kucharczyk K

Multitemperature single-strand conformation polymorphism.

Electrophoresis

Zylicz M, Wawrzynow A

Insights into the function of Hsp70 chaperones.

IUBMB Life

Zylicz M, King FW, Wawrzynow A

Hsp70 interactions with the p53 tumour suppressor protein

EMBO J

King FW, Wawrzynow A, Höhfeld J, Zylicz M

Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.

EMBO J

Genevaux P, Wawrzynow A, Zylicz M, Georgopoulos C, Kelley WL

DjlA is a third DnaK co-chaperone of Escherichia coli, and DjlA-mediated induction of colanic acid capsule requires DjlA-DnaK interaction.

J Biol Chem

Banecki B, Wawrzynow A, Puzewicz J, Georgopoulos C, Zylicz M

Structure-function analysis of the zinc-binding region of the Clpx molecular chaperone.

J Biol Chem